Akt-related signaling pathways are known to function as compensatory mechanisms by regulating multiple cellular functions.35, 36, 45 Moreover, omentin-stimulated the activation of Akt signaling has been reported to play a crucial role in the response to injurious stimulator via promoting cell survival and revascularization in muscle and heart tissues.37, 38 Therefore, to determine the underlying mechanism of omentin-mediated protection against LPS-induced ARDS, we further investigated the contribution of Akt-related signaling in vivo and in vitro. The gene discussed is AKT1; the disease is acute respiratory distress syndrome.