Inflammation plays a pivotal role in the initiation and progression of ARDS.6 Although omentin has been indicated as an anti-inflammatory adipokine in the pathogenesis of various obesity-related disorders, its specific role and underlying mechanism in ARDS remain unclear.14, 15, 16, 22 In agreement with the previous findings that omentin played an anti-inflammatory role in EC cells through inhibiting TNF-α-induced VCAM expression by blocking the NF-κB pathway,30 our present study demonstrated that omentin suppressed the inflammatory response to LPS by targeting the lung EC barrier. The gene discussed is TNF; the disease is acute respiratory distress syndrome.