Not significant differences between sufficient and insufficient subjects were found both at T1 and T2; moreover, in patients with a severe 25OHD deficiency, a higher daily insulin requirement (p<0.05) and HbA1c values (p<0.01) than other 25OHD status were found and a trend to an increase in HbA1c (p<0.0001) across 25OHD levels was observed at T1 and in HbA1c (p<0.01) and insulin requirement (p<0.05) at T2 (Table 3). Here, INS is linked to hyperinsulinemic hypoglycemia, familial, 4.