As shown in S1F Fig, a significant decrease in number of viable cells is observed in both UMSCC74A (p<0.05) and UMSCC74B (p<0.01) cells with FXR1 KD compared to control, indicating FXR1 plays a key role in oral cancer cell viability and/or survival. The gene discussed is FXR1; the disease is lip and oral cavity carcinoma.