In addition, LANA has been shown to interact with a number of host epigenetic factors (e.g. KAP1, mSin3, DNMT3a, KDM3A, Tip60, and hSET1), which may also be involved in the timing of PRC2 recruitment to the viral episome during de novo infection [10,35,38,49,50,51,52]. Here, KDM3A is linked to infection.