MRC1 and colorectal carcinoma: In addition, we analyzed the clinical features of the 21 families harboring MLH1 Ile219Val polymorphism in the presence of disease-predisposing MMR gene mutations, MMR carrier’s families showed an early mean age at CRC diagnosis (41 ± 5.35) years, although these differences were not significant (p > 0.05) (available upon request).