Significantly poorer overall survival (fixed-effect model: HR 2.83, 95 % CI 1.11–7.22; Random-effect model: HR 2.83, 95 % CI 1.11–7.22) and disease-free survival (fixed-effect model: HR 1.87, 95 % CI 1.15–3.04; Random-effect model: HR 1.96, 95 % CI 1.06–3.64) for HIF-1α expression were observed in chondrosarcoma patients without significant heterogeneity (Table 2). Here, HIF1A is linked to chondrosarcoma.