However, the prognostic role of HIF-1α expression in bone and soft tissue sarcoma has not reached a consensus since inconsistent results were reported in previous studies (Zhao et al. 2015; Kim et al. 2015; Hu et al. 2015; Guo et al. 2014; Smeland et al. 2012; Chen et al. 2012a, b, 2011; Zeng et al. 2010; Huang et al. 2010; Boeuf et al. 2010; Hoffmann et al. 2009; Mizobuchi et al. 2008; Kubo et al. 2008; Chen et al. 2008; Yang et al. 2007; Shintani et al. 2006). The gene discussed is HIF1A; the disease is soft tissue sarcoma.