Among them, a nonsynonymous SNP that results in an isoleucine to methionine substitution at position 1891 (rs3798220) and an intronic variant (rs10455872) have been confirmed to be strongly associated with increased levels of plasma Lp(a) and the risk of cardiovascular disease (Clarke et al. 2009; Li et al. 2011; Thanassoulis et al. 2013). The gene discussed is LPA; the disease is cardiovascular disorder.