As the foregoing findings reveal a hypothrombotic state in MDD-SA and MDD-NA subjects (Figs 2 and 6), we hypothesized that heparin treatment – which induces a hypothrombotic state through inactivating the extrinsic pathway proteins thrombin, FXa, and FIXa20 – may promote depression-like behavior in rodents. The gene discussed is F10; the disease is depressive symptom measurement.