SAA1 and major depressive disorder: Therefore, MDD, independent of suicidality, is associated with a proinflammatory state as evidenced by significantly higher CRP and SAA1 levels in both MDD-SA and MDD-NA relative to HC subjects (Fig. 2) accompanied by a hypothrombotic state as evidenced by significantly lower F1 + 2 levels and lower relative prothrombinase activity in MDD-SA and MDD-NA relative to HC subjects (Figs 2 and 6).