As discussed below, two inflammatory proteins (CRP, SAA1) and eight coagulatory proteins (TF, FVII, FX, FV, TFPI, APC, PCI, F1 + 2) demonstrated significantly differentiated expression in MDD-SA subjects relative to both MDD-NA and HC subjects (Figs 2 and 3). This evidence concerns the gene APC and major depressive disorder.