While Patients 5, 6, and 7 demonstrated a significant increase in nuclear YAP in tumor compared to non-neoplastic tissue, they only had a substantial increase in CCNE1 expression, with Cyr61 being downregulated in Patient 5 and unchanged in Patients 6 and 7, and CTGF unchanged in all three patients. The gene discussed is CCN1; the disease is neoplasm.