While several previous studies suggested that L-FABP might be useful for detection of AKI caused by septic shock23, 47, L-FABP might fail to perform as a better predictor of AKI compared with NGAL in septic patients with hyperlactatemia, as several different mechanisms other than renal injury might increase both lactate and L-FABP. This evidence concerns the gene LCN2 and acute kidney injury.