Although several clinical studies evaluating early AKI detection by NGAL and L-FABP showed promising results3, 4, two meta-analyses reported that not all the studies showed area under the receiver operating characteristic curve (AUC-ROC) values of above 0.85, indicating the performance of these biomarkers for early AKI detection could be improved5, 6. This evidence concerns the gene LCN2 and acute kidney injury.