KMT5A and esophageal squamous cell carcinoma: The ESCC patients were divided into three groups on the basis of their SET8 C/C, C/T and T/T genotype for Kaplan–Meier analysis, the 5 years survival rate of patients were 68.2% for C/C type, 37.7% for C/T and 44.4% for T/T, respectively (Fig. 1C).