In our previous studies, we found the rs16917496 SNP including C/C, C/T and T/T genotypes in the “seed” region of SET8 3′ UTR where miR-502 binding was associated with both cancer risk of epithelial ovarian cancer and outcome of hepatocellular carcinoma, small cell lung cancer and non-Hodgkin’s lymphomas20, 21, 22, 23. This evidence concerns the gene KMT5A and cancer.