It is noteworthy, however, that activated Fgfr3-based signalling has been shown to be Tak1 dependent in the context of multiple myeloma and bladder cancers [63], therefore not excluding the possibility that mouse blastocyst Fgf-signalling may also activate Tak1 (indicated by the dashed arrow in the model present in figure 6). The gene discussed is FGFR3; the disease is urinary bladder carcinoma.