In our study we assessed the possible circadian oscillation of classical (Aβ42, t-tau, p-tau) and candidate (Aβ38, Aβ40, sAPPα, sAPPβ, apolipoprotein E, neurogranin, YKL-40, VILIP-1) CSF AD biomarkers. The gene discussed is CHI3L1; the disease is Alzheimer disease.