Our results suggest that it is not just CaMKII expression that is important for controlling cancer cell invasion and migration, but rather that phosphorylation of CaMKII at T286 can further enhance these processes (Figs 4 and 5), indicating that abundant autonomous activation of CaMKII may result in significantly worse outcome for breast cancer patients by increasing breast cancer cell motility and invasiveness. The gene discussed is CAMK2G; the disease is cancer.