In contrast to that observed in the established breast cell lines (Fig. 1A,B), total CaMKII expression was significantly increased in primary breast cancer (Fig. 2B,G; p < 0.00001) and lymph node metastases (Fig. 2C,G; p < 0.00001) when compared to normal breast tissue (Fig. 2A). This evidence concerns the gene CAMK2G and breast cancer.