Plasma PLTP level was associated with the presence (P < 0.001) and severity (P = 0.010) of AMD and age-related maculopathy susceptibility (ARMS)2 risk genotype (GT or TT) (P = 0.012), whereas plasma MASP-1 level was associated with the presence of AMD (P < 0.001) and ARMS2 risk genotype (GT or TT) (P = 0.029). This evidence concerns the gene PLTP and age-related macular degeneration.