However, it is questionable whether the increase in PLTP and MASP-1 plasma concentration comes from the RPE, as our results cannot draw definite conclusion on the source, and it is also possible that systemic imbalances in lipid metabolism and inflammation lead to elevated plasma concentrations of PLTP and MASP-1 in patients with AMD. The gene discussed is MASP1; the disease is age-related macular degeneration.