Further, it stimulates the adiponectin secretion in obesity animal model and humans [54, 55] which activating the gene responsible for adipocyte differentiation.27 muscle and adipose tissue possess the two kinds of glucose transporter such as GLUT-1 and GLUT-4 in which GLUT-4 is an important insulin regulator [56]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.