Broad transcriptomic changes were observed in human cancers with SF3B1 mutations including MDS,11, 27 and we recently described the aberrant splicing patterns in such cancers.13 Here we perform a similar analysis on RNAseq data from Sf3b1K700E/+ mice and report that for aberrant 3′ splice sites with upstream cryptic AGs, splicing abnormalities are strikingly similar to those seen in human cancer samples, including the aberrant splice site consensus sequence (Figure 4a) and distance of aberrant 3′ splice sites from the canonical ones (Figure 4b). Here, SF3B1 is linked to cancer.