Expanding on a previous study that showed that excess dietary sugar increases fat accumulation in adult flies (Skorupa et al., 2008), Drosophila larvae fed a diet high in sucrose exhibited important aspects of obesity-related metabolic disorders, including fat accumulation, insulin resistance and hyperglycemia (Musselman et al., 2011). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.