It was suggested that thymidine led to oxidative stress in thymidine phosphorylase-overexpressing cancer cells, leading to production of stress-induced angiogenic factors, vascular endothelial growth factor, and interleukin-8 and induced matrix metalloproteinase 1, accounting for thymidine phosphorylase-induced angiogenesis [22, 25]. This evidence concerns the gene CXCL8 and cancer.