Recently, the identification of a Nedd4L missense mutation in a patient with epileptic encephalopathy and the isolation of missense mutations in highly conserved residues of Nedd4-2 in families with photosensitive generalized epilepsy has suggested that this E3 ligase, in addition to hypertension, is an epilepsy associated gene and can contribute to CNS pathologies13. The gene discussed is NEDD4L; the disease is Epileptic encephalopathy.