Although we found a tendency to an increase in the number of crosses between different arms of the maze and the time spent in the open arm for the Nedd4-2 +/− mice these data were not significant (Fig. 3F,G) suggesting that the increased activity of the Nedd4-2 mice in the open field test is not related to anxiety-related behavior. The gene discussed is NEDD4L; the disease is Anxiety.