NEDD4L and Hypertension: Recently, the identification of a Nedd4L missense mutation in a patient with epileptic encephalopathy and the isolation of missense mutations in highly conserved residues of Nedd4-2 in families with photosensitive generalized epilepsy has suggested that this E3 ligase, in addition to hypertension, is an epilepsy associated gene and can contribute to CNS pathologies13.