IgG1 and IgG3 are cytophilic and engage Fc-receptors to promote opsonic phagocytosis or killing by neutrophils; recent studies have reported that antibodies mediating opsonic phagocytosis of merozoites, or neutrophil-mediated killing, are associated with protection from malaria in children15, 39. Here, IGHG3 is linked to malaria.