TNF and Alzheimer disease: 2004). Increased TNF‐α expression in the TgAD mice could likely contribute to the microvascular abnormality in the TgAD group through inflammatory and oxidative processes as previously described in brain tissue with AD. Interestingly, these findings are similar to what we and others reported for microvascular dysfunction and NO signaling with acute lung injury such as that caused by ischemia–reperfusion (Sedoris et al. 2009).