Finally, the PRR nucleotide-binding domain and leucine-rich-repeat-containing proteins (NLRP), including NLRP3 and nucleotide-binding oligomerization domain 2 (NOD2), play multiple roles in regulating the innate immune response during virus infection through modulation of inflammasome activation, antiviral activity, and priming of adaptive immunity [11–14]. The gene discussed is NOD2; the disease is viral infectious disease.