Additionally, genes associated with cancer-acquired super-enhancers in H1299 were found to be significantly enriched in genes upregulated by the KRAS pathway (MSigDB Oncogenic Signature “Genes up-regulated in epithelial lung cancer cell lines over-expressing an oncogenic form of KRAS gene” p-value = 12.63 × 10−07 determined by GREAT)36. The gene discussed is KRAS; the disease is cancer.