Although previous reports described interactions between BRD4 and NSD2, there was a lack or enrichment of the cancer-acquired super-enhancer signature in genes changing expression after the NSD2 knock down (Supplementary Table 2), and genes contributing the most to the cancer-acquired super-enhancer signature in H1299 cells treated with JQ1 were not significantly changing after NSD2 knock down (Fig. 4d lower panel). The gene discussed is BRD4; the disease is cancer.