NSD2 and cancer: Despite previous reports proposing that BRD4 plays a role in NSD2 recruitment to chromatin, we found a rather weak overlap in the transcriptional responses to JQ1 and NSD2 depletion of direct target genes (associated with cancer-acquired super-enhancers or enriched in H3K36me2, respectively) suggesting that in cancer cell lines that overexpress NSD2 its recruitment to chromatin is independent of BRD4.