These genes (Supplementary Fig. 10) include metalloproteinases involved in tumor invasion and metastasis (MMP1 and MMP16), transcription factors and coactivators (ZEB2, E2F5, E2F7, HNF4G, MEF2C, NR4A2, NCOA7, NCOA1, CITED2) chromatin related factors (HDAC2, TET1 and HMGN3), signaling molecules (IL7, FGF12) and relevant kinases and phosphatases (EPHA7, FYN, TNIK and DUSP6). This evidence concerns the gene MMP16 and neoplasm.