These genes (Supplementary Fig. 10) include metalloproteinases involved in tumor invasion and metastasis (MMP1 and MMP16), transcription factors and coactivators (ZEB2, E2F5, E2F7, HNF4G, MEF2C, NR4A2, NCOA7, NCOA1, CITED2) chromatin related factors (HDAC2, TET1 and HMGN3), signaling molecules (IL7, FGF12) and relevant kinases and phosphatases (EPHA7, FYN, TNIK and DUSP6). The gene discussed is E2F7; the disease is neoplasm.