Both cell lines, KMS11, a multiple myeloma line which harbors the t(4;14) translocation, and RCH-ACV, a lymphoblastic leukemia line with the E1099K activating mutation, were sensitive to NSD2 depletion mediated by sh3 and sh5 (Supplementary Fig. 2d,e). This evidence concerns the gene NSD2 and acute lymphoblastic leukemia.