Both low absolute secretion (IL-12, TNF-α, GM-CSF, Eotaxin and IFN-α) and low cytokine productions relative to IFN-γ (IL-2, IL-4, IL-12, IP-10, MIG, TNF-α, GM-CSF, Eotaxin and IFN-α) could highlight a defect in TB control. The gene discussed is TNF; the disease is tuberculosis.