A common functional polymorphism (C677T) in the gene-encoding MTHFR results in a 70% reduction in enzymatic activity, in vitro, and has been associated with differences in Hcy concentration.[9,10] Previous studies on the MTHFR C677T polymorphism suggested a causal link between hyperhomocysteinemia (HHcy), characterized by elevated Hcy levels in the blood, coronary heart disease, stroke, and peripheral vascular disease.[11,12]. The gene discussed is MTHFR; the disease is peripheral vascular disease.