Of late, low HDL-c values have been associated with cancer diagnosis.[10,11] Meanwhile, apolipoprotein A1 (ApoA1), an important component of HDL-c, has been demonstrated to have a direct suppressive effect on tumor cells of melanoma in vitro and in vivo.[12] This predominant role of ApoA1 was confirmed by studies that used ApoA1 HDL-c-mimetics peptides to inhibit ovarian and colon cancer development in mouse models.[13,14]. The gene discussed is APOA1; the disease is colonic neoplasm.