Our study shows that blocking the hypoxia-inducible expression of M-CSFR in TAMs and TGF-β in glioma cells using ACF or a specific inhibitor (e.g., BLZ-945 or anti-TGF-β antibodies) impaired the hypoxia-inducible M2 polarization of TAMs. Here, TGFB1 is linked to central nervous system cancer.