We demonstrated that irradiated cancer cells redirect macrophages to secrete suppressive cytokines, and both Mertk-Fc and TGFβR inhibitor partially block suppressive cytokine secretion (Figure 4d), but that the combination of the TGFβR inhibitor together with a blocking MertkFc fusion protein was able to completely inhibit the co-culture induced switch to IL-10 production and importantly was able to restore TNFα production in response to LPS stimulation (Figure 4d). Here, TNF is linked to cancer.