The venture of all-grade hypertension occasions increased dramatically after treatment with VEGFR-TKIs: a random-effects model (I2 = 44.1, P < 0.001) yielded an RR of 3.85 (95% CI, 3.37-4.40; P < 0.001; Supplementary Table 4 and Figure S3). This evidence concerns the gene KDR and hypertensive disorder.