The pooled RR derived from a fixed-effects model (I2 = 0%, P = 0.941) revealed that the danger of high-grade hypertensive incidents among patients of cancer was significantly higher after treatment with VEGFR-TKIs (RR, 4.60, 95% CI, 3.92-5.40; P < 0.001; Supplementary Table 4 and Figure S4). The gene discussed is KDR; the disease is cancer.