However, it was of interest to note that the danger of all-grade hypertensive events decreased non-significantly in patients with R/M HSNCC (RR, 0.94; 95% CI, 0.02-44.33) or gastric cancer (RR, 0.88; 95% CI, 0.02-43.40) treated with VEGFR-TKIs, and that the danger of high-grade hypertensive events decreased non-significantly in individuals with gastric cancer (RR, 0.88; 95% CI, 0.02-43.40). This evidence concerns the gene KDR and gastric cancer.