DICER1 and endometrial carcinoma: Interestingly, somatic Dicer1 hotspot missense mutations with defective Dicer1 function in 5p miRNA production were commonly found in nonepithelial ovarian tumors, in particular in 60% of Sertoli-Leydig cell tumors, and rarely in epithelial ovarian and endometrial carcinomas [21, 22].