A recent study also suggests snoRNAs to have multiple functions in carcinogenesis with snoRNA42 acting as an oncogene in lung tumors [67], while whole-exome sequencing of DNA from two early onset lung adenocarcinoma never-smoking patients revealed germline mutations in Nop58, therefore adding weight to the role of snoRNPs in lung cancer [68]. Here, NOP58 is linked to lung adenocarcinoma.