Apart from the discovery of known c-Myc targets this transgenic disease model allowed for an identification of novel c-Myc-responsive genes in lung cancer and included arginase1, ribonucleotide reductases M1 and M2, uridine-cytidine kinase 2, meiotic recombination 11a, nucleoplasmi 3, nucleolar proteins and importin 4 whose altered expression can now be linked to adenocarcinomas of the lung. This evidence concerns the gene IPO4 and lung adenocarcinoma.