This enzyme catalyzes the conversion of L-lactate and NAD into pyruvate and NADH; its increased tissue expression was associated with poor outcome in lung cancer patients and was strongly associated with tumor recurrence, however did not correlate with NFκB p65 tissue expression or FDG uptake in PET imaging of NSCLC patients [35, 36]. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.