On the other hand, “hub genes” of four other modules contain POU2F3 (↑), CENPH (↑), PCSK6 (↑) and HERC2 (↑), BCAR3 (↑), DOHH (↑), NLK (↑), SCN2A (↑), CACNA2D3 (↓) and CTNND2 (↓), which were commonly reported related to cancer (Supplementary Figure S19). This evidence concerns the gene HERC2 and cancer.