NOTCH1 and acute lymphoblastic leukemia: Twenty-one variations had not previously been reported and thus were considered as novel T-ALL driver mutations, including 3 in NOTCH1 (p.N1603K, p.P2475fs and p.L2326fs) as well as novel predicted deleterious mutations in the well-known X-linked PHF6 (p.E221* and p.G226fs) and KDM6A/UTX (p.Q692*) [8, 28] (Figure 1 and Supplementary Table S3).