Mature T-ALL patients 547, 759 and 636 were shown to carry translocations t(1;14)(p34;q11), t(11;14)(p13;q11) and t(10;14)(q24;q11) respectively, leading to the juxtaposition of the TAL1, LMO2 and TLX1/HOX11 oncogenes to the T-cell receptor alpha/delta (TCRA/D) at locus 14q11 [18–20]. This evidence concerns the gene TLX1 and acute lymphoblastic leukemia.