LEF1 and acute lymphoblastic leukemia: Other frequently altered gene/pathway categories in T-ALL include signal transduction (PTEN, JAK1, JAK3, NF1, NRAS, IL7R and FLT3), transcription factors (WT1, LEF1, ETV6, GATA3 and BCL11B) as well as chromatin remodeling (EZH2, SUZ12, EED and KDM6A/UTX) [15].