The APOBEC3 gene family, including APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3E, APOBEC3F, APOBEC3G, and APOBEC3H, plays pivotal roles in intracellular defense against viral infections [25, 26]. The gene discussed is APOBEC3B; the disease is viral infectious disease.