We pointed our attention on IL-10, as a survival factor that may be involved in this effect given (i) ibrutinib intensely induces gene expression and secretion of IL-10 in NLCs, (ii) CLL cells express IL-10 receptor as previously demonstrated [39], (iii) elevated serum IL-10 levels are associated with worse CLL patients survival [40]. This evidence concerns the gene IL10 and B-cell chronic lymphocytic leukemia.