In human squamous cell lung carcinoma [16], breast carcinoma [17], human osteosarcoma [18], oral squamous cell carcinoma [19], and cutaneous squamous cell carcinoma [20], c-Fos overexpression was found to correlate with poor prognosis; while in refractory colorectal carcinoma [21] and epithelial ovarian carcinoma [22], elevated c-Fos expression was reported to be a good prognostic marker. The gene discussed is FOS; the disease is osteosarcoma.