The compound was identified as a candidate anti-cancer lead compound in a luciferase reporter screen for small molecule p53-independent inducers of TNF-related apoptosis-inducing ligand (TRAIL) gene transcription in (TRAIL-resistant) bax-null HCT116 human colorectal cancer (CRC) cells [1, 2]. This evidence concerns the gene TNFSF10 and colorectal carcinoma.