TP53 and neoplasm: Referred to as TRAIL-inducing compound 10 (TIC10) based on the phenotype underpinning its discovery as an anti-tumor agent, ONC201 was selected as the lead compound for clinical development due to its favorable therapeutic index, lack of genotoxicity, drug-like chemical properties, penetration of the blood-brain barrier, p53-independent efficacy in a panel of refractory solid tumor cell lines, and single-dose anti-tumor activity in vivo [1, 2].