Knockdown of TLR9 by siRNA reduced the increase in plasma creatinine and urea in response to polymicrobial sepsis in mice (Liu et al. 2012). TLR9 knockout reduced AKI in CLP‐induced septic mice (Dear et al. 2006, Yasuda et al. 2008). Possibly via stimulation by mitochondrial DNA (Tsuji et al. 2015). The gene discussed is TLR9; the disease is acute kidney injury.