TLR4 and acute kidney injury: 2012). It has been reported that endotoxemia attenuates the dynamic response of the tubuloglomerular feedback mechanism (TGF) in rats (Nitescu et al. 2010). TLR4 might be a key component as CLP‐treated mice upregulates cTAL COX‐2 and while developing AKI, but not if TLR4 deficient (El‐Achkar et al. 2007). COX‐2 upregulation in cTAL and adjacent macula densa affects the TGF in a proconstrictive manner (Araujo & Welch 2009).