KRAS and cancer: Interestingly, and as demonstrated in Figure 1, downregulation of PI3K p110α significantly decreased cellular viability in HCT116 (Figure 1A) and SW480 (Figure 1B) cancer cell lines, regardless of the genetic alterations in KRAS and/or PIK3CA. In particular, the inhibition of PI3K p110α in HCT116 cells induced an almost 50% decrease in cellular viability (Figure 1A, p< 0.0001).