KRAS and colorectal carcinoma: Overall, our data indicates that PI3K p110α inhibition induces apoptosis in KRAS/PIK3CA mutant HCT116 cells and a cell cycle arrest in KRAS mutant SW480 cells, suggesting that different mechanisms may be involved in mediating the inhibitory effects of PI3K p110α in CRC cell lines with distinct mutations, namely those in KRAS and PIK3CA.