VWF and melanoma: The corresponding quantification revealed that only 2.6 ± 1.8% of vessels in the healthy skin contained VWF fibers; this was significantly increased to 22.0 ± 2.3% in the Ret tumor tissue (Figure 2C, Supplementary Table S1) and to 27.6 ± 2.0% in B16F10 melanomas (Supplementary Figure S1; Supplementary Table S2).