We recently reported that sucrose-non-fermenting protein kinase 1 (SNF1)/AMPK-related protein kinase (SNARK), the fourth member of 14 ARKs [7], supported replication of hepatitis C virus (HCV), a causative agent of HCC, in genome-wide RNAi screen [8], and enhanced profibrogenic transforming growth factor (TGF)-β signaling in HCC cells [9], suggesting SNARK as an attractive pharmacological target. Here, NUAK2 is linked to hepatocellular carcinoma.