NUAK2 and neoplasm: Both HepG2 and PLC/PRF/5 cells were conferred resistance to DSF at lower concentrations (Figure 5C and 5D) by the excessive supply of SNARK (Supplementary Figure S5F), which was not observed with the kinase-dead K81M and unphosphorylated T208A mutants [9] in HepG2 cells (Supplementary Figure S5G) and PLC/PRF/5 cells (Supplementary Figure S5H), confirming SNARK as a tumor promoter and a pharmacological target.