Again DDC, with anti-cancer effects via chelating into metal ions [20] and reported to significantly improve the overall survival in breast cancer patients [30], demonstrated unique profiles of cytotoxicity to HCC cells, and indicated the effects by DSF are to be kept even after being metabolized at least reducing SNARK expression (Figure 4G); lately further improvement in stable delivery and anti-cancer effects of DDC was reported in vivo [31]. The gene discussed is NUAK2; the disease is cancer.