Together, these findings reveal that Piwil2, whose expression is restored by the combination of E6 and E7 in cervical cancer, may reactivate the “core” somatic cell reprogramming factors c-Myc, Nanog, Oct4, Sox2, and Klf4 by regulating the shift of acetylation and trimethylation of H3K9, thus initiating cell reprogramming and contributing to TIC formation (Figure 8). This evidence concerns the gene KLF4 and cervical carcinoma.