Moreover, in cervical cancer cells, Piwil2 overexpression also induced a significant upregulation of c-Myc, Nanog, Oct4, Sox2, and Klf4 (Figure 7c), increased the proportion of cells that were ALDH, MSCA-1, and ABCG2 positive (Figure 7d) and subsequently increased cisplatin resistance (Figure 7e). The gene discussed is POU5F1; the disease is cervical carcinoma.