In parallel the dynamic histopathological process, in this study, the IHC results revealed that the cytoplasm and nuclei in CIN2/3 and cervical cancer specimens showed positive staining for Piwil2, whereas only 4 out 13 CIN1 cases weakly expressed Piwil2 in the cytoplasm but not in the nuclei, and no Piwil2 was expressed in normal cervical samples. This evidence concerns the gene PIWIL2 and cervical carcinoma.