IL17A and periodontitis: Besides, over-production of inflammatory mediators including Interleukin-1β (IL-1β) and Interleukin-17 (IL-17) by the host cells such as fibroblasts, other periodontal cells, and infiltrated induced cells at the site plays a role in the destruction of periodontal tissues.[4-5] New methods for treatment of periodontitis target the etiologic factors to eliminate the chain of reactions caused by bacteria in the human immune system, because these reactions lead to the release of inflammatory mediators that are responsible for the destruction of connective tissue and bone.