In accord with evidence that many genes are implicated in schizophrenia,45 cytoarchitectural changes in the schizophrenia brain would be expected to be milder than in reeler mice, probably resulting from small alterations to multiple signaling pathways, compared with large effects from mutations in the RELN gene as reported in autosomal recessive lissencephaly.46 The gene discussed is RELN; the disease is schizophrenia.