Moreover, reelin continues to regulate synaptic remodeling in the adult brain.43 Reelin supplementation into brains of wild-type mice increased dendritic density and synapse potentiation, to improve “cognitive ability”.44 It is important to realize that the difference in cortical lamination in the reeler mutant brain is far more severe than in the schizophrenia post-mortem brain. Here, RELN is linked to schizophrenia.