A balanced t(1;11) translocation was first described as a single locus major risk factor for major psychiatric disorder, including schizophrenia, bipolar disorder, and recurrent major depression, in a multiply affected Scottish pedigree with a maximum parametric LOD score of 7.1.1,2 The translocation breakpoint lies within the Disrupted in schizophrenia 1 (DISC1) and DISC1FP1/Boymaw genes.3DISC1 encodes a multi-functional scaffold protein that mediates several processes that have been implicated in the etiology of major psychiatric disorders. The gene discussed is DISC1; the disease is major depressive disorder.