BMX and ischemia: Further study revealed that transient depletion of BMX strongly reduced secretion of IL-8 in human fibroblasts stimulated by TNF-α and IL-1β.[7] In neuronal injury induced by H2O2 or ischemia, BMX is activated and suppressing BMX activity protects against neurodegeneration.[23] Altogether, an essential role for the tyrosine kinase BMX in cytokine signaling and inflammation has been established.