CNP and Sepsis: As a cleavage product of proCNP, Amino-terminal pro-C-type natriuretic peptide (NT-proCNP) is the N-terminal fragment of the C-type natriuretic peptide precursor.[65] The amounts of NT-proCNP are equal to CNP in human plasma and NT-proCNP is considered to be a more reliable indicator of the extent of CNP synthesis.[65] Results of a study show that the levels of circulating NT-proCNP can discriminate poly trauma patients without traumatic brain injury who develop sepsis from those who do not.[66]