Each one is made of 5 protomers of 206 amino acid residues, and belongs to the pentraxin family of calcium-dependent ligand-binding plasma proteins.[36] CRP is mainly synthesized in the hepatocytes, and its transcription is reduced by the cytokine IL-6, which is predominantly released by macrophages in response to various types of systemic inflammation, including infections or trauma.[36–38] Therefore, it is a sensitive marker of inflammation and tissue damage. This evidence concerns the gene IL6 and infection.