CALCA and Sepsis: Its levels show a rapid decrease when infection is resolved, whereas many other inflammatory biomarkers still have high levels during the acute-phase response.[28] For predicting post-traumatic sepsis, studies have shown the rapid kinetics of PCT, with levels peaking at 24–48 h after trauma and rapid decrease in non-complicated patients, whereas with constant high levels in septic patients.[4] Continuous high levels or secondary increases of PCT are predictors of sepsis.[27,28,30–34] PCT as a biomarker is useful in the prediction and early diagnosis of sepsis in trauma patients.