PPIG and Sepsis: As for septic patients, acute liver injury was significantly higher in males than in females, and the mortality in males was higher than in females.[48] CYP activity, reflected by the aminopyrine breath test, is also a clinically useful tool for predicting outcome in the early stages of sepsis.[49] CYP activity returned to normal levels in the survivor patients while they remained low in the non-survivors at the late phase of sepsis.