Thoracic epidural anesthesia, which is associated with regional sympathetic block, reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in the liver of septic rats.[61] Similarly, modulation of the sympathetic nervous system by blocking α2A-adrenoceptor significantly reduced serum levels of pro-inflammatory cytokines, chemokines, liver enzymes (AST and ALT) and lactate.[62] In contrast, some catecholamines, mimicking sympathetic nerve activity, can induce an inflammatory response and exacerbate the hepatic dysfunction observed during sepsis. Here, GPT is linked to Sepsis.