The downregulation of CYP enzymes is due to the reduction of aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (Arnt), two critical transcription factors involved in the regulation of CYP1A2 mRNA.[29] Furthermore, AhR and Arnt expressions are inversely correlated with pro-inflammatory cytokines in sepsis. This evidence concerns the gene ARNT and Sepsis.