In this regard, Dam et al. (27) and Longo et al. (38) stated that "calicin, a basic protein that is almost exclusively located in the posterior part or calyx of the sperm nuclear theca, appeared to be absent in globozoospermic cells", thereby indicating that impaired development of the spermspecific skeleton may affect protein localization in globozoospermia (39,40). The gene discussed is CCIN; the disease is Globozoospermia.